2006-2008 – auditor at KPMG Audit CJSC.
2008-2012 – economist in the analytical department of Dragon Asset Management LLC.
In 2009, appointed Deputy General Director for Economic Security of Karlivka Machine-Building Plant PJSC, and from 2009 to 2012, served as General Director of the company.
2012-2018 – investment manager at System Capital Management PJSC.
2018-2019 – member of the Supervisory Board of Lemtrans LLC.
2021 – Acting Chairman of the Board of JSC Ukrainian Railways.
2021-2023 – Chairman of the Board of JSC Ukrainian Railways.
In March 2023, Oleksandr Kamyshin was appointed Minister for Strategic Industries of Ukraine.